Therefore, we have quantified the interference that perflubron causes in the measurements of eight widely used oximeters and CO-oximeters. A preliminary report indicates that this new oxygen-carrying fluorocarbon interferes with the measurements of CO-oximeters. Perflubron emulsion is expected to be in clinical use soon as a non-hemoglobin blood substitute. Some blood substitutes caused obvious interference, such as negative carb oxyhemoglobin readings however, the findings indicate that cooximeters will generally give less accurate but clinically useful measurements in the presence of the hemoglobin-based blood substitutes that were tested. IMPLICATIONS: We investigated the effects of five hemoglobin-based blood substitutes on the measurements of eight different cooximeters. Our findings indicate that the instruments will give less accurate but clinically useful measurements in the presence of these hemoglobin-based blood substitutes. In some cases, the interference was even more obvious: five of six cooximeters gave negative carb oxyhemoglobin readings on one particular product. By contrast, when compared with readings on controls, the test instruments yielded measurements of the fractional concentrations of oxy-, deoxy-, carboxy-, and methemoglobin that showed greater instrument-to-instrument disparities and larger standard deviations about the all-instrument means. The instruments yielded measurements of total hemoglobin concentration in undiluted blood substitutes that were generally not more variable than those on the control material. A cooximeter control was used to compare the eight different instruments' measurements on unaltered human hemoglobin. (Cambridge, MA), Hemoglobin Therapeutics, and Hemosol, Inc. The five blood substitutes in this study were obtained from Apex Bioscience (Research Triangle Park, NC), Baxter Healthcare Corp. Therefore, we investigated the effects of five hemoglobin-based blood substitutes on the measurements of eight different oximeters and cooximeters: the AVL Omni 6, the AVOXimeters 10, the Ciba Corning (now Bayer) CC270 CO-oximeter, the Instrumentation Laboratory Synthesis 35, the IL482 and IL682 CO-oximeters, and the Radiometer OSM3 Hemoximeter. UNLABELLED: The blood substitutes now being developed from molecularly modified hemoglobin interfere with a wide variety of clinical analyzers, but their effects on cooximeters are unknown. A cooximeter control was used to compare the eight different instrumentsвЂ™ measurements on unaltered human hemoglobin. The blood substitutes now being developed from molecularly modified hemoglobin interfere with a wide variety of clinical analyzers, but their effects on cooximeters are unknown.

Avox co oximeter